DIAMONDS is a Generic Data Management and Data Integration Platform for the Life Sciences developed by TNO. DIAMONDS, has a broad scope and is used by many and very diverse Life Science projects. From estimating the Toxicity of Compounds, Safety Assessment of Targets, Allergenicity of Proteins up to Modelling Health parameters and providing Personalized Nutritional and Lifestyle Advice.
DIAMONDS brings together Data, Knowledge and Algorithms. Data ranges from Clinical studies and Omics data to Personalized Health data. Traceable from original Raw measurements to Cleaned, Processed data ready to use. Knowledge ranges from Biological Knowledge from Curated databases and Textmining to manually Curated Triples from our Experts. All captured and connected to Source information through Standardized Pipelines and Workflows Protocols. Diverse tools and algorithms such as Statistical tools, Text mining methods, Scripts, Decision Trees, Bayesian/Dynamic Networks and Network Visualization.
DIAMONDS brings together Data, Knowledge and Algorithms. Data ranges from Clinical studies and Omics data to Personalized Health data. Traceable from original Raw measurements to Cleaned, Processed data ready to use. Knowledge ranges from Biological Knowledge from Curated databases and Textmining to manually Curated Triples from our Experts. All captured and connected to Source information through Standardized Pipelines and Workflows Protocols. Diverse tools and algorithms such as Statistical tools, Text mining methods, Scripts, Decision Trees, Bayesian/Dynamic Networks and Network Visualization.
DTOX is a DIAMONDS project that integrates knowledge and data relating to the chemical structure, kinetics, metabolism, system biology and toxicity of substances with Omics data obtained from alternative experimental models for biological verification. This enables faster, more informed choices when investigating the safety of chemical substances for product development and/or registration.
The current risk-assessment method for chemical substances requires a great deal of research. This can be done more quickly and effectively by combining areas of expertise and available data. For this purpose, TNO uses the DIAMONDS approach, a ‘new-style’ toxicological risk assessment method that makes it possible to determine the toxic properties of a chemical substance at an early stage, thereby reducing costs and preventing unnecessary testing on animals.
The current risk-assessment method for chemical substances requires a great deal of research. This can be done more quickly and effectively by combining areas of expertise and available data. For this purpose, TNO uses the DIAMONDS approach, a ‘new-style’ toxicological risk assessment method that makes it possible to determine the toxic properties of a chemical substance at an early stage, thereby reducing costs and preventing unnecessary testing on animals.
TargetTri is an online platform for profiling drug targets in terms of safety and efficacy. TargetTri integrates text-mining, data-mining and network biology to obtain a complete view on effects exerted by target modulation. Queries can be initiated from either a protein/gene or a therapeutic indication.
At TNO, we know drug targets and we can help you assess your target in an early phase of drug development. By combining our diverse capabilities, we offer services that extract, integrate and interpret data regarding your target and translate this into valuable information for decision making. With a track record in target safety assessment for many years, we do offer additional services in the area of efficacy assessment and biomarker identification. In addition, we offer tailor-made solutions and are developing the target intelligence platform TargetTri together with the pharmaceutical industry to be used as an in-house tool for more efficient target assessments.
At TNO, we know drug targets and we can help you assess your target in an early phase of drug development. By combining our diverse capabilities, we offer services that extract, integrate and interpret data regarding your target and translate this into valuable information for decision making. With a track record in target safety assessment for many years, we do offer additional services in the area of efficacy assessment and biomarker identification. In addition, we offer tailor-made solutions and are developing the target intelligence platform TargetTri together with the pharmaceutical industry to be used as an in-house tool for more efficient target assessments.
Psycat is a DIAMONDS project that provides a valid instrument designed to detect psychosocial problems in children. It is an intelligent web-based questionnaire that smartly decides which questions to ask based on the given answers so far. Psycat is available for parents of children in the ranges of 2 to 4 and 7 to 11 years.
Psycat is an efficient and reliable alternative for existing instruments for detecting psychosocial disorders in children. When compared to existing questionnaires, e.g. the Strengths and Difficulties Questionnaire (SDQ), Psycat offers the following advantages: It gives reliable and valid information about the nature of the mental problem, Psycat is a fast and adaptive instrument, It provides easy readable graphic results.
Psycat is an efficient and reliable alternative for existing instruments for detecting psychosocial disorders in children. When compared to existing questionnaires, e.g. the Strengths and Difficulties Questionnaire (SDQ), Psycat offers the following advantages: It gives reliable and valid information about the nature of the mental problem, Psycat is a fast and adaptive instrument, It provides easy readable graphic results.
Substance Information System (SIS) is a public tool developed on the TNO DIAMONDS platform that allows users to search and find information on hazardous substances. The tool collects and organizes information from diverse sources to provide an integrative resource on substance properties, safety, health effects, exposure, and application by business sectors.
In collaboration with the Dutch Ministry of Social Affairs and Employment (SZW), TNO has developed SIS with the aim of preventing occupational diseases through better organization and dissemination of available information on hazardous substances. Within the tool, users may either start by searching for a substance or a sector.
This tool is freely available, please register or log in below to get direct access to SIS.
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In collaboration with the Dutch Ministry of Social Affairs and Employment (SZW), TNO has developed SIS with the aim of preventing occupational diseases through better organization and dissemination of available information on hazardous substances. Within the tool, users may either start by searching for a substance or a sector.
This tool is freely available, please register or log in below to get direct access to SIS.
ECEL 3.0 is a public tool developed on the DIAMONDS platform that offers a searchable library of occupational and environmental Risk Management Measures (RMM). Supporting registrants to evaluate the quantitative effectiveness of a specific RMM or downstream users (industry, research, consulting) on the most suitable RMM for a given exposure or emission scenario.
TNO and CEFIC have developed an integrated Risk Management Measure library (ECEL v3.0) as part of the CEFIC LRI B15 project. ECEL v3.0 offers a comprehensive source of information on RMMs and applies a statistical method to derive and visualize effectiveness values for both occupational and environmental RMM scenarios.
This tool is available free of charge. Please register or log in below and get direct access to ECEL3.0
LOGIN to START DIRECTLY or REGISTER for IMMEDIATE ACCESS
TNO and CEFIC have developed an integrated Risk Management Measure library (ECEL v3.0) as part of the CEFIC LRI B15 project. ECEL v3.0 offers a comprehensive source of information on RMMs and applies a statistical method to derive and visualize effectiveness values for both occupational and environmental RMM scenarios.
This tool is available free of charge. Please register or log in below and get direct access to ECEL3.0
The LICARA Innovation Scan is a public tool that allows a preliminary but swift assessment of benefits and risks for innovative products.
The LICARA Innovation Scan is based on the LICARA nanoSCAN previously developed by TNO and EMPA, focusing on the evaluation of innovative nanoproducts. In the Perocube project, TNO has extended the application of the scan to all innovative products including, but no longer exclusively, nano products.
Both tools are available free of charge, please register or log in below and get direct access to the new version of the LICARA nanoSCAN and/or the new LICARA Innovation Scan.
LOGIN to START DIRECTLY or REGISTER for IMMEDIATE ACCESS
The LICARA Innovation Scan is based on the LICARA nanoSCAN previously developed by TNO and EMPA, focusing on the evaluation of innovative nanoproducts. In the Perocube project, TNO has extended the application of the scan to all innovative products including, but no longer exclusively, nano products.
Both tools are available free of charge, please register or log in below and get direct access to the new version of the LICARA nanoSCAN and/or the new LICARA Innovation Scan.
TWOC aims help clinicians, the scientific community, policy makers and politicians and the public at large to get near real time accurate, expert-annotated and specific information in a modern, user friendly and easily accessible format.
The basis for the research service provided by TWOC is mined data from literature, real world observations (mostly clinical but also self-reporting in COVID-19 apps), and outcomes from intervention trials concerning the worldwide pandemic of COVID-19. Domain experts will review, annotate and filter the information to consolidated information for citizens and for policy makers. The goal of this ‘trusted Hotel concept’ is to assist academic and private researchers, and help the community at large to get near real time accurate, expert-annotated and specific information on COVID-19 in a modern, customised format.
The basis for the research service provided by TWOC is mined data from literature, real world observations (mostly clinical but also self-reporting in COVID-19 apps), and outcomes from intervention trials concerning the worldwide pandemic of COVID-19. Domain experts will review, annotate and filter the information to consolidated information for citizens and for policy makers. The goal of this ‘trusted Hotel concept’ is to assist academic and private researchers, and help the community at large to get near real time accurate, expert-annotated and specific information on COVID-19 in a modern, customised format.
The Hotspot Scan is a public tool that allows a systematic and efficient assessment of potential hotspots in the life cycle of innovative products. To perform a full LCA can be a time-consuming and challenging task, the HotSpotScan provides an intermediate assessment focusing on the strongest human health and environmental impacts based on establishing all the material flows.
The Hotspot Scan, originally created in FutureNanoNeeds, has been augmented in the Perocube project to a tool that allows to scan for hotspots in the life cycle of innovative products.
This tool is available free of charge. Please register or log in below and get direct access to the new HotSpot Scan.
LOGIN to START DIRECTLY or REGISTER for IMMEDIATE ACCESS
The Hotspot Scan, originally created in FutureNanoNeeds, has been augmented in the Perocube project to a tool that allows to scan for hotspots in the life cycle of innovative products.
This tool is available free of charge. Please register or log in below and get direct access to the new HotSpot Scan.
The Contamination Estimate Calculator is a public tool that provides the user with a first indication of the unintended allergen presence (UAP) in their product. The calculator guides the user through entry of data relevant for calculating and documenting UAP. The approach uses a simple calculation and can be one of the inputs used for risk management decision making.
The contamination estimate tool was originally developed in EU-project iFAAM (2013-2017). iFAAM received funding from the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement n° 312147.
The tool will be made publicly available free of charge by TNO as the Contamination Estimate Calculator on July 1st 2022.
The contamination estimate tool was originally developed in EU-project iFAAM (2013-2017). iFAAM received funding from the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement n° 312147.
The tool will be made publicly available free of charge by TNO as the Contamination Estimate Calculator on July 1st 2022.